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AY2023 Drug Action Assignment, PC, Singapore: Drugs A and B bind to the same type of receptors. These two drugs were studied using organ bath experiments
University Republic Polytechnic (RP)
Subject AY2023 Drug Action Assignment
Posted on: 2nd Dec 2023

AY2023 Drug Action Assignment, PC, Singapore: Drugs A and B bind to the same type of receptors. These two drugs were studied using organ bath experiments

Section A (30 marks)
Attempt the 3 quizzes in POLITEMall by 8th January 2024.
You will be given 15 minutes for each attempt and only 2 attempts for each
quiz. The higher score will be taken for grade calculation.

Section B (24 marks)
Attempt all the case-based questions below and submit this document with
your answers in the SA 2.0 submission folder by 8th January 2024.

1. Drugs A and B bind to the same type of receptors. These two drugs were
studied using organ bath experiments, and their graded dose-response curves were plotted as shown in Figure 1

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(a) From the list of drugs given in Table 1, identify ONE drug that could be Drug
A and another ONE drug that could be Drug B. Justify your answers. (6 marks)

(b) With reference to the Drug B that you have chosen from Table 1, state ONE
therapeutic use and ONE side effect of Drug B. Explain your answers. (4 marks)

(c) Drug A binds to Receptors X and Y. With reference to Figure 2, which
Receptors (X or Y) is Drug A more selective for? Explain your answer. (2 marks)

2. Figure 3 shows the plasma drug concentration versus time curves of 200mg Drug K was administered via oral route to two healthy adult volunteers, Jenny and Sally, who are of the same age, body weight, and body type.
a) Compare pharmacokinetics characteristics of Drug K when administered to Jenny and Sally, your answer should include but not be limited to the following:
i. The area under the curve (AUC)
ii. elimination kinetics order Explain your answers.

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b) Provide THREE possible reasons to explain ONE of the Drug K pharmacokinetics differences recognized for Jenny and Sally in part (a).

c) Drug K is metabolized by CYP2D6 to inactive metabolites in the liver. Identify ONE drug in Table 2 that should be avoided when patient is taking Drug K, and explain the clinical consequences if both drugs are taken concurrently.

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